"Aging-related Hematopoietic Stem Cell Intrinsic
and Microenvironmental Signals in AML Transformation"

​

PROJECT SUMMARY

​

Acute myeloid leukemia (AML) commonly occurs in elderly individuals and may develop from pre-AML conditions such as age-related clonal hematopoiesis (ARCH), myelodysplastic syndromes (MDS), or myeloproliferative neoplasms (MP). Research suggests that age-related declines in blood-forming stem cells and signals from the aging environment can play a significant role in AML progression. This program aims to use advanced genetic tools and single cell technology to study the evolutionary changes in mutations and environmental influ-ences, to understand how aging bone marrow supports the growth of AlL-initiating clones.

​

​

We Also Thank PI's: Emmanuelle Passegue,PhD: Project Leader for Project 1, Ulrich Steidl (Albert Einstein): Project Leader for Project 2, Raul Rabadan, PhD (Columbia University): Core B Leader, Jellert Gaublomme, PhD: Core B Co-Investigator, Matthew Greenblatt (Weill Cornell): Core B Co-investigator, Aaron Viny, MD: Core A Co-Investigator,
Jianhua Hu, PhD: Core A Co-Investigator

​

​